2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P991220
    AL002 98%
    AL002 is a humanized monoclonal immunoglobulin G1 (IgG1) antibody and a TREM2 agonist antibody for use in neurological disease research.
    AL002
  • HY-RS16308
    mt-Co1 Mouse Pre-designed siRNA Set A

    mt-Co1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for mt-Co1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    mt-Co1 Mouse Pre-designed siRNA Set A
  • HY-RS17433
    Piezo1 Mouse Pre-designed siRNA Set A

    Piezo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Piezo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Piezo1 Mouse Pre-designed siRNA Set A
  • HY-W003486
    5,7-Dichloropyrazolo[1,5-a]pyrimidine 57489-77-7
    5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is a pyrazolopyrimidine phosphodiesterase 10A (PDE10A) inhibitor (Ki=24 μM). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used in the study of schizophrenia.
    5,7-Dichloropyrazolo[1,5-a]pyrimidine
  • HY-W012264
    3-O-Methyldopa monohydrate 200630-46-2 98.87%
    3-O-Methyldopa monohydrate (3-Methoxy-L-tyrosine monohydrate) is a significant metabolite of L-DOPA produced through the action of catechol O-methyltransferase (COMT). Unlike its precursor, 3-O-Methyldopa does not serve as a substrate or inhibitor of L-amino acid decarboxylase activity. Additionally, the inhibition of COMT can amplify the anti-Parkinson effects of L-DOPA.
    3-O-Methyldopa monohydrate
  • HY-W013113
    BTMPS 52829-07-9 ≥98.0%
    BTMPS is a nicotine receptor (nAChR) antagonist that can lessen the negative effects of morphine on rats.
    BTMPS
  • HY-W037282
    O-Desmethyl quinidine 70877-75-7 99.05%
    O-Desmethyl quinidine (Cupreidine) is an orally active metabolite of Quinine (HY-D0143). O-Desmethyl quinidine reduces frequency of cramps in rats with spinal cord injury and shows low blood toxicity.
    O-Desmethyl quinidine
  • HY-W129456
    Isaxonine 4214-72-6 99.54%
    Isaxonine acts as a modifier of the surface pH of the bilayer. Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery. Isaxonine is a neurotrophic agent.
    Isaxonine
  • HY-W419700
    L-Glutamic acid ammonium 7558-63-6 ≥98.0%
    L-Glutamic acid ammonium is an excitatory neurotransmitter.
    L-Glutamic acid ammonium
  • HY-W742564
    Acacetin-7-O-β-D-galactopyranoside 80443-15-8 98.57%
    Acacetin-7-O-β-D-galactopyranoside is a flavonoid that can be isolated from flower heads of Chrysanthemum morifolium. Acacetin-7-O-β-D-galactopyranoside inhibits AChE activity and can be used for research of Alzheimer’s disease.
    Acacetin-7-O-β-D-galactopyranoside
  • HY-W751418
    N-Nervonoyl taurine 1942003-30-6 ≥99.0%
    N-Nervonoyl taurine ((Z)-2-tetracos-15-enamidoethanesulfonic acid) is a fatty acid-taurine conjugate derived from nervonic acid. N-Nervonoyl taurine is a substrate of fatty acid amide hydrolase (FAAH) discovered during metabolite profiling.
    N-Nervonoyl taurine
  • HY-121883S1
    Lignoceric acid-d3 851073-55-7 ≥99.0%
    Lignoceric acid-d3 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research.
    Lignoceric acid-d3
  • HY-W010155R
    Tryptophol (Standard) 526-55-6
    Tryptophol (Standard) (Indole-3-ethanol (Standard)) is an analytical standard of Tryptophol (HY-W010155). This product is intended for use in research and analytical applications.Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces Apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy.
    Tryptophol (Standard)
  • HY-W012998R
    2,3-Pentanedione (Standard) 600-14-6
    2,3-Pentanedione (Standard) is the analytical standard of 2,3-Pentanedione. This product is intended for research and analytical applications. 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans.
    2,3-Pentanedione (Standard)
  • HY-W342604R
    N-Acetylputrescine (Standard) 5699-41-2
    1,4-Dicaffeoylquinic acid (Standard) is the analytical standard of 1,4-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production.
    N-Acetylputrescine (Standard)
  • HY-107749
    ML 190 1355244-02-8 98.2%
    ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively.
    ML 190
  • HY-124157
    AA41612 433690-62-1 ≥98.0%
    AA41612 is a potent antagonist of melanopsin-mediated phototransduction.
    AA41612
  • HY-131979
    TP-040 2757254-99-0 98.59%
    TP-040 (O-GlcNAcase-IN-1) is a potent and novel OGA inhibitor with an IC50 value of 46 nM.
    TP-040
  • HY-13418G
    Dorsomorphin dihydrochloride (GMP) 1219168-18-9 98%
    Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs).
    Dorsomorphin dihydrochloride (GMP)
  • HY-14880B
    Bavisant dihydrochloride hydrate 1103522-80-0 ≥98.0%
    Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride hydrate can be used for attention-deficit hyperactivity disorder (ADHD) research.
    Bavisant dihydrochloride hydrate
Cat. No. Product Name / Synonyms Application Reactivity